Doerksen attended the Simon Fraser University. Her initial major was Science, but her interest in acting caused her to change it to Theatre, and she received a BFA from Simon Fraser University. Doerksen began working in film in 2005, with her first on-screen roles being in CW's Smallville and Showtime's The L Word.
In 2006 she provided her voice in Mattel's 2006 animated film, The Barbie Diaries and later starred in SpikeTV's 'Blade: The Series. In 2011 Doerksen was nominated for a Best Performance Leo Award for her role in the short film, Alchemy and other Imperfections.